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Exercise-associated hyponatremia, renal function, and nonsteroidal antiinflammatory drug use in an ultraendurance mountain run.

Page AJ, Reid SA, Speedy DB, Mulligan GP, Thompson J

Clin J Sport Med. 2007 Jan ; 17(1): 43-8

OBJECTIVE: To study biochemical parameters and renal function in runners completing a 60 km mountain run and to investigate the incidence of exercise-associated hyponatremia (EAH). To assess the effects of nonselective nonsteroidal antiinflammatory medication (NSAIDs) and cyclooxygenase-2 (COX-2) selective nonsteroidal antiinflammatory medication (COXIBs) on these parameters.

DESIGN: Observational cohort study.

SETTING: Kepler Challenge 60 km mountain run, Te Anau, New Zealand, December 2003. PARTICIPANTS: One hundred thirty-one of the 360 runners entered in the race were prospectively enrolled as volunteers on the day before the race.

MAIN OUTCOME MEASURES: Subjects were weighed at race registration the day before the race and at the finish line. Blood was taken within 5 minutes of finishing and was analyzed for serum sodium, creatinine, urea, and potassium concentrations, and hematocrit. Participants were questioned about medication use in the 24 hours before and during the race (NSAIDs, COXIBs, other medications). RESULTS: Complete data sets were obtained on 123 runners. Five athletes were biochemically hyponatremic [(Na) 130-134 mM] and four were hypernatremic [(Na) 146-148 mM]. Hyponatremia was associated with a mean weight gain of 1.32 kg (range, -1.5 to 1.6 kg). Serum [Na] varied inversely with weight change. Estimated creatinine clearance did not vary with percent weight loss. Estimated creatinine clearance declined with increasing runner age. Sixty-five percent of runners did not use any medication, whereas 20% had used NSAIDs and 15% had taken COXIBs. There were no statistically significant differences between NSAID and COXIB users in any measured parameters or between all NSAID and COXIB users when compared with nonusers.

CONCLUSIONS: Mild asymptomatic EAH was found to occur in 4% of the volunteer ultraendurance mountain runner study group and was associated with a mean weight gain of 1.32 kg (range, -1.5 to 1.6 kg) during the race. Seven percent gained weight but remained normonatremic, suggesting other compensatory mechanisms. Hypernatremia was found in 3% and was associated with a mean weight loss. Postrace serum sodium concentration varied inversely with percent weight change. Runners using any NSAID were more likely to become hyponatremic. Estimated creatinine clearance increased with increasing age. Elevated serum creatinine concentration at the end of the race returned to normal when remeasured the week after the race. Thirty-five percent of runners were found to use NSAIDs or COXIBs. The measures of weight change and of serum sodium, potassium, urea, and creatine concentration did not differ between NSAID and COXIB users or between all nonsteroidal antiinflammatory users and nonusers.

Via HubMed Abstracts

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Shaun Carroll is pounding the pavements near his Thetford home to be in peak condition for London’s Marathon having qualified after four attempts.

The 35-year-old service engineer, who has lost three and a half stone since his fitness regime three years ago said: “At school I was always over weight and would walk the cross country course.”

Now the former Charles Burrell pupil is up with the lark to pursue his hobby which has taken him to Newcastle’s Great North Run and the 10k Breckland Run last year.

With regular training sprints and uphill runs, the father of two from Fairfields, is aiming to raise in excess of £1,200 for Phab, a leading national children’s charity that creates opportunities for the disabled and able-bodied to come together through local clubs, holidays and activities.

Read the rest at Thetford and Brandon Times

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You can still sign up for the Kaiser Permanente Napa Valley Marathon, a 26.2-mile race which takes runners from the starting line at Rosedale Road and Silverado Trail in Calistoga at 7 a.m. to the finish line at Vintage High School in Napa on March 4.

Race officials are continuing to accept entries for the 29th annual event, and will do so all the way up to March 3, the day of the marathon’s annual Sports and Fitness Expo. It runs from 9 a.m. to 5 p.m. at the Napa Valley Marriott Hotel & Spa and includes the marathon’s popular Marathon College, an innovative speaker/seminar program that includes a “faculty” composed of respected running authorities and celebrity runners.

Read the rest at the Napa Valley Register

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ferranp2001 posted a photo:

Marathon tag from Flickr

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An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus.

Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R, Robinson LE

Metabolism. 2007 Mar ; 56(3): 332-8

Obesity and type 2 diabetes mellitus (T2DM) have been associated with a state of chronic low-grade inflammation. We examined the effect of exercise without weight loss on circulating inflammatory biomarkers in previously sedentary lean men and obese men with and without T2DM.

Middle-aged men (8 lean, 8 obese, and 8 obese with T2DM) performed 60 minutes of aerobic exercise 5 times per week for 12 weeks without a reduction in body weight. Subjects underwent a hyperinsulinemic-euglycemic clamp before and after the 12-week exercise program to assess insulin sensitivity. Circulating interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), and C-reactive protein concentrations were measured by sandwich enzyme-linked immunosorbent assay before and after the exercise intervention.

Body fat was measured using magnetic resonance imaging, and waist circumference was recorded for each subject pre- and postexercise intervention. Waist circumference and plasma IL-6 concentrations were significantly lower (P < .05) after exercise training despite no change in body weight or insulin sensitivity. There were no correlations between insulin sensitivity and IL-6. Fasting plasma PAI-1 concentration was significantly lower in the lean group compared with the obese group both pre- and postexercise intervention (P < .05). There were no changes in C-reactive protein or PAI-1 concentrations after exercise training.

A 12-week exercise intervention led to reductions in waist circumference and fasting IL-6 concentrations in previously sedentary lean and obese men with or without T2DM, demonstrating significant changes in clinically relevant diabetes-related parameters despite no change in body weight.

From HubMed Abstracts

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